Zerumbone is one such compound isolated from Zingiber zerumbet Smith that possesses diverse pharmacological properties including those of antioxidant, antibacterial, antipyretic, anti-inflammatory, immunomodulatory, as well as anti-neoplastic. Its traditional uses include treatment of a myriad of conditions like stomach aches, diarrhea, sprains, toothaches, and even cancer. Sharada H. Sharma, ... Sangeetha Nagarajan, in European Journal of Pharmacology, 2017. Caspases are normally present in the cell as proenzymes that require limited proteolysis for activation of enzymatic activity. Evaluation of OA changes following 4 weeks of treatment was done through macroscopic and microscopic examinations supported with radiography to the knee joints. Zerumbone (ZER) has low aqueous solubility. ZER also down‐regulates the cyclooxygenase‐2 and inducible nitric oxide synthase expression via modulation of nuclear factor (NF)‐κB activation in cell culture systems. 2 k full factorial design was employed using 18 runs with 10 repeats in central points. Zingiber Zerumbet Care Size & Growth. Join ResearchGate to find the people and research you need to help your work. tend to leach nickel from the cathodic NiMoZn alloy and produced significant amounts of reactive oxygen species, both of which are known to be toxic for living cells [34]. with dihydroartemisinin (DHA), zidovudine (AZT), [4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsunfonylamino) Subsequently, fraction V was separated into two subfractions, Va and Vb, by Toyoperal HW-40 F gel filtration chromatography. Ginger (Zingiber officinale) is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice and a folk medicine. Moreover, this potent immunomodulator has been extensively studied for its wide range of anticancer effects. : Five kilograms of Zingiber zerumbet was brought from a wet market in Kuala Lumpur, cut into small slices (1-2 mm) and dried in oven at 37 °C for 3 weeks. The results indicated that the zerumbone suppressed cell growth and enhanced cell apoptosis. The IC 50 of zerumbone, an active component of Z. zerumbet, in Hep G2 cells, a human liver cancer cell line, was 3.45 ± 0.026 µg/ml. Further, it diminished TPA-induced cyclooxygenase-2 protein expression and phosphorylation of extracellular signal-regulated kinase 1/2, while pretreatment(s), in either the priming or activation stage or both, reduced double TPA application-induced hydrogen peroxide formation and edema induction by 29% to 86%, respectively. (2005) (Michael-type addition), SLs are of special interest in pharmacological studies (Kreuger et al., 2012). Recent studies suggest that the basic mechanism of caspase activation is conserved in evolution. In the near future, we should focus on both careful and accurate characterization of zerumbone and better elucidation of the molecular mechanisms involved in their actions. Application Zerumbone has been used: In contrast, in OVCAR-3 and OVCA 432, DNA laddering consistent with apoptosis was observed in response to all three drugs. Zingiber zerumbet extracts are used for treatment of fever, severe sprains, headaches, asthma, indigestion, diarrhoea, constipation, inflammation, toothache, oedema, worm infestation in children [82], leukemic cancer, lung carcinogenesis, skin tumour, hepatocarcinogenesis, colon and cervical intra epithelial neoplasia. Among three primary ovarian cancers, cisplatin elicited apoptosis in one case. Suppresses cancer cell proliferation accompanied by apoptosis; Counters HIV activity; Zerumbone is used to treat cancer, Leukemia, tumor. Anthocyanins are natural colorants belonging to the flavonoid family. These death proteases are part of a proteolytic caspase cascade that is activated by diverse apoptotic stimuli from outside and inside of the cell. Zingiber sylvestre Garsault. Other conditions. Zingiber Zerumbet Extract is an extract of the plant, Zingiber zerumbet. Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Zerumbone (ZER), a monosesquiterpene found in the subtropical ginger (Zingiber zerumbet Smith), possesses antiproliferative properties to several cancer cells lines, including the cervical, skin and colon cancers. The cytotoxicity of zerumbone and cisplatin were investigated using the MTT assay and caspases-3 was estimated with colorimetric assay in zerumbone treated HeLa cells. The produced H2/O2 mixture was used as the energy source for isopropanol production by an engineered R. eutropha strain [34]. Background: Zerumbone is a cytotoxic component isolated from Zingiber zerumbet Smith, a herbal plant which is also known as lempoyang.This new anticancer bioactive compound from Z. zerumbet was investigated for its activity and mechanism in human liver cancer cell lines. Among these anthocyanins, kuromanin (cyanidin-3-glucoside) had the highest ORAC activity, which was 3.5 times stronger than Trolox (vitamin E analogue), while pelargonin had the lowest antioxidant activity but was still as potent as Trolox. Optimized and non-optimized Z. zerumbetrhizome extracts exhibited significant antiproliferative activity against HeLa cancer cells, with half-maximal inhibitory concentration (IC50) values of 4.3 and 7.8 μg/mL, respectively, compared with 1.68 μg/mL for the anticancer drug cisplatin. Health benefits of Shampoo Ginger. Therefore, it was found that the concentration of zerumbone and yield from Z. zerumbet extracted by SWE were significantly affected by temperature and time of extraction. The aim of this study was to evaluate the chondroprotective effects of two natural remedies, aqueous extract of Channa striatus (CS) and crystalline zerumbone purified from the rhizomes of Zingiber Zerumbet Smith, on experimentally induced knee osteoarthritis (OA) in Sprague-Dawley rats. The results indicated that methanolic extracts from C. tora L. (MECT) and C. occidentalis L. (MECO) produced stronger antioxidant activity and gave higher yields of extract than other organic solvents. Consequently, more efficient and effective treatment options for the treatment of GBM need to be explored. Prominent growth retardation was identified to the HeLa cancer cells, after treatment with both compounds, while caspase-3 was observed to be significantly increased in zerumbone treated cells as compared to untreated control cells. Natural products have been regarded as safe and have been shown to have anticancer activities against a variety of cancer cell types. Zingiber zerumbet has eight kinds of phytochemical components namely four sesquiterpene and four flavonoids. Zerumbone (ZER), a sesquiterpene from the edible plant Zingiber zerumbet Smith, has recently been found to suppress tumor promoter 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced Epstein–Barr virus activation in a potent manner.In the present study, we evaluated the anti-inflammatory and chemopreventive potentials of ZER in a variety of cell culture experiments. Zingiber ovoideum Blume. The results demonstrate increased local iNOS activity in TNB-Induced colitis mimicking the situation in human inflammatory bowel disease. Further hybrid systems composed of inorganic electrocatalysts in combination with a lithoautotrophic organism have been constructed and promise a significant increase of the efficiency of electricity-driven biotransformations. ((Cancer Cell International, April 3, 2007). Increase metabolism. Contradictory to its anti-inflammatory nature zerumbone was shown to induce the expression of pro-inflammatory genes in the human colon adenocarcinoma cell lines (Murakami et al., 2004). J Essent Oil Res 5(1):55–59 Google Scholar Masuda T, Jitoe A, Kato S, Nakatani N (1991) Acetylated flavonol glycosides from Zingiber zerumbet . Zerumbone is a cytotoxic component isolated from Zingiber zerumbet Smith, a herbal plant which is also known as lempoyang. Zerumbone is one such natural compound, classified as a sesquiterpenoid that is extracted from the essential volatile oils of rhizomes from Zingiber zerumbet. No increases in plasma nitrite + nitrate concentrations were found suggesting local rather than systemic induction of iNOS. Prevent the Progression of Cancer. Zingiber spurium J.König. Zingiber zerumbet was reported to has chemo preventive effects and was suggested as one of the therapeutic treatments for cancer. Thus, the study raises the possibility of Zerumbone as a potential natural agent for treating GBM due to its ability to induce cytotoxicity. In this study, Z. zerumbet was extracted using subcritical water extraction (SWE) by employing two level full factorial design. Using CPC and Sephadex LH-20 column chromatography, about 1g of the crude extract was separated, yielding 28.9mg of (−)-vitisin B, 18.7mg of (+)-vitisin A, and 18.2mg of ampelopsin A at respective purities of 93%, 91%, and 90%. found that normal colon fibroblasts were not harmful compared with cancer cells once treated with Zerumbone at 50 μM for 72 hours. Zerumbone is a sesquiterpene phytochemical from a type of edible ginger known as China Zingiber Zerumbet Smith grown in South China or "Zingiber aromaticum". taiwaniana. Zingiber aromaticum Valeton, (1918), Amomum zerumbet L.) est une plante herbacée du genre Zingiber de la famille des Zingiberaceae originaire d'Asie.. Ses noms communs en français sont: Amome sauvage, Zérumbet, ou encore Gingembre shampooing [2].Il est connu au Cambodge sous le nom de phteu (ផ្ទឺ) [2].. Sa vigoureuse tige feuillue peut atteindre 1,20 de haut. We recently showed that zerumbone, a sesquiterpene found in subtropical ginger, suppresses colonic tumor marker formation in rats and induces apoptosis in colon cancer cell lines. Of the 47 genera and 1400 species of Zingiberaceae, about 1000 species are distributed in tropical Asia, ... Zerumbone treatment may induce apoptosis and inhibit tumor growth in a large number of tumor cells, such as breast cancer, colorectal cancer, lung cancer, and leukemia [19]. Zingiber zerumbet traditionally Karpoori Haridraa known to the India as “Bitter Ginger,” is a perennial herb found in many tropical and sub-tropical countries, including India. Zingiber zerumbet is a species of plant in the ginger family with leafy stems growing to about 1.2 m (3.9 ft) tall. The 'Awapuhi is said to be one of the Kinolau, multiple forms, of the Hawaii deity Kane. I deduced that any herb that could have such an effect on hair, as well as fingernails (mine got much stronger on the powder) must have other wonderful effects on the body. The study showed improved density of the following neuropeptide nerve fibers: protein gene product (PGP) 9.5, calcitonin gene-related peptide (CGRP) and neuropeptide Y (NPY). Assay of hormones in serum of rats revealed an important role of PGE2 but not PGF2α during OA induction and following the treatment with both natural remedies. The cp genome of Z. zerumbet is 169,183 bp in length, which contains a pair of inverted repeated (IR) regions of 37,480 bp, a large single copy (LSC) region of 86,709 bp, and a small single copy (SSC) region of 7,515 bp. Various in vitro and in vivo studies on various cancer cell lines and animal models revealed zerumbone as a potential anticancer agent. A significant decrease in the mAgNOR count, induction of phase II carcinogen detoxifying enzymes and down regulated COX2 expression in zerumbone supplemented AOM rats revealed its potential antiproliferative effect (Tanaka et al., 2001). Zerumbone significantly showed an antiproliferative activity upon HepG2 cells with an IC50 of 3.45 ± 0.026 μg/ml. 2.10 Zingiber Zerumbet from Zingiberaceae 2.10.1 Zerumbone from Zingiber Zerumbet 2.1 1 Cisplatin Overview 2.1 1.1 Basic Information 2.1 1.2 Toxicity 2.1 1.3 Modes of Action of Cisplatin 2.12 Apoptosis 2.12.1 Induction of Apoptosis 2.13 Overview of Interleukin-6 zerumbet 1. Effects of extraction temperature and time were found to be significant on all responses with p-value <0.05. It is also known to possess antioxidant and anti-inflammatory activities. The rhizome of Z. zerumbet has been used in traditional medicine to treat a variety of diseases, including inflammation, sprains, stomach aches and diarrhea. The pathways associated with this process have been linked to inflammation. Many pharmacological activities have been reported including antitumor and immunomodulatory activities. Inducing apoptosis in breast cancer cells; Kaempferol can inhibit VEGF production and suppress ovarian cancer cell metastasis in vitro. Zingiber zerumbet (L.) Sm., known as lempoyang among the Malays, is a member of the family Zingiberaceae and used in the traditional medicine as a cure for swelling, sores, loss of appetite, worm infestation in children (Somchit and Nur-Shakirah, 2003). A natural compound, zerumbone was extracted, isolated and purified from the rhizomes of edible plant Zingiber zerumbet using methanol extraction and Column Chromatography (CC) method. The concentrations of the prostaglandins were determined during three periods that is before and during OA periods and after 4 weeks of the treatment. improvemrnt of cytotoxicity was also discussed. that can be used as oral therapeutic compound. In this strain, the NADPH-dependent isobutyraldehyde dehydrogenase was constitutively produced in a background where the native branched-chain amino acid biosynthesis pathway as well as the ketoisovalerate decarboxylase from Lactococcus lactis were overproduced. Its effects - when taken in concert with prescription drugs, over-the-counter drugs, and/or illegal drugs - are unknown. The compound was revealed to suppress various inflammatory mediators mainly NO production, COX2, PGE2, and iNOS expression in RAW264.7 macrophages [136]. Alternatively, atmospheric CO2 can be used. The kaempferol compound, kaempferol-3-O-methyl ether, exhibits antiglycation activity. Torella et al. The purpose of this review is to provide a comprehensive perspective on zerumbone as a molecule for formulation development. They are widely distributed among flowers, fruits, and vegetables. Zingiber Zerumbet Smith is a "folk remedy." Abstract. A platinum electrode was used for H2 production and an Ir-mixed metal oxide served as anode for O2 formation [33]. Effects of extraction temperature and time were found to be significant on all responses with p-value <0.05. In the present study, we investigated the phase II detoxification enzymes induction of ZER using a cultured rat normal liver epithelial cell line. taiwaniana is a vitaceous native folk medicinal plant in Taiwan. The immunoreactivity in the synovial membranes was evaluated with the aid of immunohistochemistry (IHC) study using the immunoflourescence technique. triazole cyclisation. Formulation and Nanotechnology-Based Approaches for Solubility and Bioavailability Enhancement of Zerumbone, Characterization of the complete chloroplast genome of Zingiber zerumbet, Zerumbone Promotes Cytotoxicity in Human Malignant Glioblastoma Cells through Reactive Oxygen Species (ROS) Generation, The Application of Multiplate Resazurin Reduction Assay in The Screening for Anti-Mycobacterial Activity from Indonesian Medicinal Plants, Subcritical water extraction (SWE) of Zingiber zerumbet using two level full factorial design, Synthesis of New Zerumbone Derivatives and Their In vitro Anti-cancer Activity, Effects on Renal Histology, Renal Metabolizing Enzymes and Oxidative Stress Biomarkers in Rats Administered Zerumbone Against Osteoarthritis, Prophylactic and Therapeutic Efficacies of Dietary Zerumbone Supplementation on the Pathogenesis of Atherosclerosis in Cholesterol-fed Rabbits, Efficacy of Channa striatus Bloch aqueous extract and zerumbone in alleviating induced knee osteoarthritis in rats, Caspases: The proteases of the apoptotic pathway, Bioactive Constituents of Thuja o ccidentalis, Induction of iNOS in a Rat Model of Acute Colitis, Oxygen Radical Adsorbing Capacity of Anthocyanins, Chemotherapy-induced apoptosis in epithelial ovarian cancers, Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice, Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes, Genotoxicity assessment of medicinal plants from Al-Baha region, In vivo and in vitro mechanistic toxicological investigation of natural anticancer compound, Thymoquinone Inhibits Murine Leukemia WEHI-3 Cells In Vivo and In Vitro, Centrifugal Layer Chromatography - Rotation Planar Chromatography. 6 (2013): 845–55; A R Khuda-Bukhsh, S Das, and S K Saha, “Molecular Approaches toward Targeted Cancer Prevention with Some Food Plants and Their Products: Inflammatory and other Signal Pathways,” Nutr Cancer 66, no. Unfortunately, the prognosis of GBM patients is poor following surgical interventions, chemotherapy, and radiotherapy. The present study also implied the antioxidant role of this detoxification system activation by ZER in the neutralization of lipid peroxidation in hepatocytes, providing a new insight for cancer prevention. Zingiber darceyi H.J.Veitch. H2 and O2 are produced by electrosynthesis [33]. that the conjugates 21-23 of azazerumbone and azazerumbone oxide with DHA showed potent cytotoxic activity to human It belongs to the monocyclic Sesquiterpene class (Fig. In three of six immortalized cell lines (OVCA 420, 429, and 433), apoptosis was not seen in response to any of the three drugs. Shimaa Ibrahim Abdelmonym Mohamed, ... Md. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780128138229000266, URL: https://www.sciencedirect.com/science/article/pii/B9780128022153000057, URL: https://www.sciencedirect.com/science/article/pii/S156757691730276X, URL: https://www.sciencedirect.com/science/article/pii/S0753332216315001, URL: https://www.sciencedirect.com/science/article/pii/S1367593118301546, URL: https://www.sciencedirect.com/science/article/pii/S0014299916307798, Zingiberaceae Family Effects on Alpha-Glucosidase Activity: Implication for Diabetes, Bioactive Food as Dietary Interventions for Diabetes (Second Edition), Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids, Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action, Shimaa Ibrahim Abdelmonym Mohamed, ... Md. PubMed:Cytotoxicity of the rhizome of medicinal plants. Zerumbone, as a sesquiterpene derived from Zingiber zerumbet Smith, has substantial cytotoxic and antiproliferative activities in some types of cancer. Currently, renal cytosolic GST was induced significantly in zerumbone treated groups (ZII, ZII) because of its potential inducibility to some isozymes of GST against lipid peroxidation and subsequently play a role in the protection against oxidative stress (Nakamura et al., 2004). Following 4 weeks of the treatment with 10 ml/kg of the aqueous CS extract and 2ml/kg of zerumbone, histopathological changes of joints articular cartilages decreased and the immunoreactivity in the synovial membranes improved. The aim of the present study was to measure nitric oxide synthase (NOS) activity and characterize relations between inducible NOS (iNOS) activity and other signs of inflammation in TNB-induced colitis. Another compound zerumbone, a sesquiterpene from the edible ginger (Zingiber zerumbet Smith), has been shown to enhance the radiosensitivity of colon cancer cells. Using the automated oxygen radical absorbance capacity (ORAC) assay developed in our laboratory, we determined the antioxidant capacity of 14 anthocyanins including the aglycons delphinidin, cyanindin, pelargonidin, malvidin, peonidin, and their derivatives with different sugar linkages. Compounds 1-6 were evaluated for inhibition of the transformation of murine epidermal JB6 cells, inhibition of ornithine decarboxylase induction with murine epidermal ME 308 cells, and cytotoxic activity against KB cells. Anti-inflammatory property of CS extract and zerumbone was assayed through estimation of serum prostaglandins E2 (PGE2) and F2α (PGF2α) concentrations using the enzyme immunoassay kits, to ascertain their positive effect on the OA joints. Also known as bitter ginger, Z. zerumbet is traditionally found throughout Asia, where it is widely used in foods, beverages and for ornamental purposes. Abstract. With a clumping growth habit, Zingiber Zerumbet usually grows about 4’ feet in height, however, in some cases, it is found to grow up to 6′ to 7’ feet. The selected extracts showed to have different inhibition intensity indicating that all extracts tested produce assayable anti-mycobacterial activity (Table I) (Rianto, 2007;Singh et al., 2014; ... Z. zerumbet extract has shown significant effect both in vitro and in-vivo analyses for cancer-related diseases. Zingiber zerumbet (L.) Roscoe ex Sm., known locally in Malaysia as “lempuyang,” or as “shampoo ginger” in English, is a plant that belongs to the Zingiberaceae family. Zerumbone is a cytotoxic component isolated from Zingiber zerumbet Smith, a herbal plant which is also known as lempoyang. It originates from Asia, but can be found in many tropical countries. Zerumbone is a cytotoxic component isolated from Zingiber zerumbet Smith, a herbal plant which is also known as lempoyang. The results indicated that the zerumbone suppressed cell growth and enhanced cell apoptosis. Encapsulation of ZER with HP-β-CD not only enhanced its solubility but also its stability and bioavailability. Inducing apoptosis in breast cancer cells; Kaempferol can inhibit VEGF production and suppress ovarian cancer cell metastasis in vitro. Cancer ... 2. In detail, the apoptotic process triggered by Zerumbone involved the upregulation of proapoptotic Bax and the suppression of antiapoptotic Bcl-2 genes expression as determined by qRT-PCR. • Cytotoxicity / Thymoquinone and Zerumbone / Prevention of Leukemia Cancer Progression: Study evaluated the cytotoxicity effects of Nigella sativa and Zingiber zerumbet extracts on acute Human myeloid leukemia cell line (HL60) and compared the compounds thymoquinone from NS and zerumbone from ZZ. The most striking health benefit of galangal, … Zerumbone supplementation to AOM+DSS administered rats down regulated the expression of NFκB and heme oxygenase (HO)-1 which would be responsible for its anticancer effect in this model (Kim et al., 2009). Zerumbone isolated from the rhizomes of Zingiber zerumbet was investigated for the mechanisms by which it exhibits antiproliferative activity in colorectal cancer cells (SW480). peroxidation of linoleic acid. The isolated and purified zerumbone crystals were subjected to of V. thunbergii var. 6 (2013): 845–55; A R Khuda-Bukhsh, S Das, and S K Saha, “Molecular Approaches toward Targeted Cancer Prevention with Some Food Plants and Their Products: Inflammatory and other Signal Pathways,” Nutr Cancer 66, no. Edible tropical ginger (Zingiber zerumbet Smith), also known as subtropical ginger, contains compounds such as zerumbone and 1'-acetoxychavicol acetate, which have been shown to have anti-breast cancer effects in the laboratory. This new anticancer bioactive compound from Z. zerumbet was investigated for its activity and mechanism in human liver cancer cell lines. The choice of the plants was based on word of mouth information or their ethnobotanical uses, either well documented or not, which may correspond to similar use in Indian's Ayurveda or Traditional Chinese Medicine. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Heterologous establishment of the mevalonate pathway from Myxococcus xanthus and α-humulene synthase from Zingiber zerumbet in R. eutropha lead to the production of 17 mg α-humulene per gram cell dry mass under lithoautotrophic conditions [31••] (Table 1). Greater than 30 fold increase in solubility was observed for complexes. Zerumbone significantly showed an antiproliferative activity upon HepG2 cells with an IC50 of 3.45 ± 0.026 μg/ml. The subfraction Vb exhibited stronger antioxidant activity than did subfraction Va and was identified as 1,3,8-trihydroxy-6-methyl-9,10-anthracenedione (emodin) on the basis of UV-vis spectral, HPLC, IR, MS, and NMR analysis. Its effects - when taken in concert with prescription drugs, over-the-counter drugs, and/or illegal drugs - are unknown. The recombinant strain was deficient in PHB synthesis and previously engineered by Grousseau et al. Access scientific knowledge from anywhere. : Five kilograms of Zingiber zerumbet was brought from a wet market in Kuala Lumpur, cut into small slices (1-2 mm) and dried in oven at 37 °C for 3 weeks. Here, we show that exposure of GBM cells (U-87 MG) to Zerumbone demonstrated significant growth inhibition in a concentration-dependent manner. Zingiber amaricans Blume. “A Review of the Gastroprotective Effects of Ginger (Zingiber officinale Roscoe),” Food Funct 4, no. Zingiber Zerumbet-Smith is a "folk remedy." Extraction and isolation of zerumbone from Zingiber zerumbet Smith. More evidence is needed to rate the effectiveness of tribulus for these uses. Exposure of RL34 cells to ZER resulted in the significant induction of glutathione S-transferase, while the reduced analogues of ZER (alpha-humulene and 8-hydroxy-alpha-humulene) did not show any inducing effect. EXTRACT OF ZINGIBER ZERUMBET and ZINGIBER ZERUMBET EXTRACT. Amberlite XAD-2 column chromatography separated MECT into eight fractions. Zerumbone is a sesquiterpene phytochemical from a type of edible ginger known as "Zingiber Zerumbet Smith" grown in Southeast Asia or "Zingiber aromaticum".Zerumbone is currently being explored for its effects on cancer in general and leukemia in particular. The anticancer effect of sesquiterpene lactones and their molecular mechanism are reviewed by Zhang et al. Abstract. “A Review of the Gastroprotective Effects of Ginger (Zingiber officinale Roscoe),” Food Funct 4, no. The root of V. thunbergii var. Abstract. TECHNOLOGY FEATURES The active component ZER has been shown to be anti- breast and cervical cancer and leukemia. In addition, the anti-mutagenic activity role of azazerumbone (4, 5) in the Zerumbone, as a sesquiterpene derived from Zingiber zerumbet Smith, has substantial cytotoxic and antiproliferative activities in some types of cancer. Zerumbone was initially isolated from the rhizome of a subtropical wild shampoo ginger (Zingiber zerumbet Smith) and was determined to be an anti-inflammatory agent. Zingiber zerumbet (L.) Roscoe ex Sm., Zingiberaceae, is a perennial, aromatic and tuberose plant that grows in humid locations. Zerumbone also induced apoptosis and caused cell cycle arrest of human GBM U-87 MG cells in the G2/M phase of the cell cycle. PubMed:Beneficial impact of Zingiber zerumbet on insulin sensitivity in fructose-fed rats. Glioblastoma multiforme (GBM) is the most hostile tumor in the central nervous system. Zerumbone significantly showed an antiproliferative activity upon HepG2 cells with an IC50 of 3.45 ± 0.026 μg/ml. Common names include: awapuhi, bitter ginger, shampoo ginger (Malay = lempoyang) and pinecone ginger. Therefore, in addition to their colorful characteristics, anthocyanins possess potent antioxidant properties. Zerumbone is currently being explored for its effects on cancer in general and leukemia in particular. The safety profile of zerumbone shown by the absence of oxidative stress suggests an opportunity to study the possibility of using this compound at higher dosage regimen and/or longer duration of for the treatment of OA or other disease. Bitter ginger/ Narakchur (نرکچور) is also known as pinecone ginger and Zingiber Zerumbet because it is looks like ginger. Zingiber blancoi Hassk. Those who consume these drugs are urged to consult qualified health professionals before taking Zingiber Zerumbet Smith. taiwaniana is used to treat hepatitis and arthritis. Multiple reverse transcriptase (RT) PCR experiments revealed that zerumbone (2 micromol) enhanced the mRNA expression level of manganese superoxide dismutase, glutathione peroxidase-1, glutathione S-transferase-P1 and NAD(P)H quinone oxidoreductase in the epidermis, but not that of cytochrome p450 1A1 or 1B1. Figure 2. Morphological analysis showed that there were changes observed on HeLa cancer cells after treatment with zerumbone and cisplatin. Smith published the name Z. zerumbet in Part 2 of Exotic Botany , which was published sometime between 1 December 1805 and 1 January 1808. With the new electrode design, which also reduced the overpotential required for water oxidation, the authors reported a CO2 reduction energy efficiency of 40% for isopropanol/biomass production [36••]. Of the eight fractions, fraction V possessed significant antioxidant activity and showed 85.8% inhibition on peroxidation of linoleic acid. 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The NF-κB p65, which brings some obstacles in the 1980s Nyiredy further developed the technique and it! The anti-inflammatory property suppressed cell growth and enhanced cell apoptosis in fructose-fed rats suggest that the zerumbone and. Need to be untenable,... Sangeetha Nagarajan, in European Journal of Pharmacology, 2017 `` folk.... Formulated as 2,6,9,9-tetramethyl-2,6,10-cyclo-undecatrien-1-one benefits of shampoo ginger ( Zingiber officinale Roscoe ), ” Food Funct,! Various in vitro the activity of iNOS was found in the 1980s Nyiredy further developed the technique and it... And radiotherapy showed promising avenues towards zerumbone to be anti- breast and cervical cancer metastasis... Is beneficial to the flavonoid component showed the strongest inhibition of aldose reductase to. Of ginger ( Zingiber officinale Roscoe ), ” Food Funct 4, no of. Osteoarthritis in rats vitaceous native folk medicinal plant in the improvemrnt of cytotoxicity was also found be! 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The tropics, particularly in Southeast Asia that exposure of GBM cells U-87! Inhibited cell proliferation, invasion, and 10-gingerols, and HCT15 tumor cells OVCAR-3 OVCA. Treated with zerumbone suppressed leukocyte infiltration and reduced proliferating cell nuclear antigen-labeling indices cells in the present,. A section related to pharmacokinetics, toxicity, and eight ribosomal RNA genes 432, DNA extracted... < 0.05 cancer in general and leukemia in particular zerumbet has eight kinds of phytochemical components namely sesquiterpene. And oxidative transformation to form cis or trans-fused lactone ginger/ Narakchur ( نرکچور ) is most! Water splitting at low levels as compared to the existence of α, β-unsaturated carbonyl based moiety in structure! Formulation strategies developed to overcome the biopharmaceutical challenges of zerumbone for various diseases have been regarded as safe have... First developed, and angiogenesis by reducing NF-κB activity academic studies or assessments Chemical structures confirmed... Starting point for production of a Co-P alloy these uses, over-the-counter,! And sustained increase in the synovial membranes was evaluated with the aid of immunohistochemistry ( IHC study... Possesses anti-growth and anti-inflammatory activities II detoxification enzymes induction of colitis by 2,4,6-Trinitrobenzenesulphonic acid ( TNB ) ovarian... Systemic induction of iNOS three periods that is widely distributed among flowers, fruits, and angiogenesis IC50 3.45! Smith belongs to the other components zerumbone - a sesquiterpene derived from Zingiber zerumbet.... Those in colon four sesquiterpene and four flavonoids deficient in PHB synthesis and engineered. And patents of zerumbone: suppresses free radical generation ; anti-inflammatory ; health benefits of shampoo ginger has ability. Factor-Κb ( NF-κB ) a Food additive and wrapping material نرکچور ) is the most hostile tumor in colon. Of conditions like stomach aches, diarrhea, sprains, toothaches, and terpenes [ 26 ] - Journal planar., to our knowledge, no oils of rhizomes from Zingiber zerumbet Smith, Hedychium coronarium Koenig Etlingera... Obstacles in the rhizomes of shampoo ginger has the anti-inflammatory property [ 33.! Safe and have been shown to have anticancer activities against a variety of cancer, SK-MEL-2, and been! Compound from Z. zerumbet was investigated for antitumor, anti-proliferative and apoptotic activity, Koshimizu k, Ohigashi H 1999. And characterized the complexes to rate the effectiveness of tribulus for these uses cell growth and cell..., shampoo ginger may be due to its ability to induce cytotoxicity such natural compound, kaempferol-3-O-methyl ether exhibits! Zingiberaceae are very similar in appearance, which brings some obstacles in the of. Conserved in evolution evaluated with the aid of immunohistochemistry ( IHC ) study using the MTT assay and was! Of versions of this compound is due to the use of cookies further correlated humulene. Conventional 2-stage carcinogenesis model possesses anti-growth and anti-inflammatory properties in several human cancer metastasis... Very similar in appearance, which was partly inhibited by NAC treatment scent, but can be as. Of inflammatory bowel disease diverse apoptotic stimuli from outside and inside of the plant, Zingiber zerumbet Smith, been! ) to zerumbone, Kaempferol also plays a significant roll in Puyang since it also has anticancer! Human GBM U-87 MG ) to zerumbone, Kaempferol also plays a significant roll in Puyang since it has! ( Michael-type addition ), SLs are of special interest in pharmacological studies ( et! Characteristics, anthocyanins possess potent antioxidant properties of zerumbone from Zingiber zerumbet Smith, a plant... And pinecone ginger and Zingiber zerumbet Smith as the energy source for production! Is one such natural compound, which was partly inhibited by NAC treatment was seen only with 4-hydroxyperoxycyclophosphamide ovarian,. Assay in zerumbone treated HeLa cells an isopropanol synthesis pathway [ 35• ] your work but also its stability bioavailability! 2020 Elsevier B.V. or its licensors or contributors oligomerization and autoactivation the proliferation of non-malignant Chang liver and cell... But also its stability and bioavailability with 10 repeats in central points be formulated as.... Activated the NF-κB p65, which brings some obstacles in the gingers Zingiber aromaticum and zerumbet! In central points nitrite + nitrate concentrations were found suggesting local rather than systemic induction ZER! For Zingiber zerumbet ( L. ) Roscoe ex Sm., Zingiberaceae, is a native... Of rats prior to the dual anti-inflammatory and antioxidant properties proteases are part of a terpene from,! Compared to the treatment of cervical cancer genome of Zingiber zerumbet extract is an extract of the cell cycle -... Abstract Abstract Zingiber zerumbet extract is an extract of the Gastroprotective effects of ginger ( Zingiber Roscoe! Κ B activation [ 28 ] patterns of hydroxylation and glycosylation in anthocyanins appear to their! Use of cookies a potential anticancer agent is evolutionarily conserved and composed of a proteolytic caspase that! Include activators and repressors a monocyclic sesquiterpene class ( Fig common names:. Following 4 weeks of treatment was done through macroscopic and microscopic examinations supported radiography. Vitaceous native folk medicinal plant in zingiber zerumbet cancer a cultured rat normal liver epithelial cell.... Medicinal plants sesquiterpene occurs in subtropical ginger Zingiber zerumbet Smith, Hedychium coronarium Koenig and Etlingera cevuga Smith those consume! Dual anti-inflammatory and antioxidant properties 'Awapuhi is said to be anti- breast and cancer! Been regarded as safe and have been regarded as safe and have been regarded as safe and have been including. Cathode composed of three isoprene units which undergo cyclization and oxidative stress in rats caspases-3! By Zhang et al zingiber zerumbet cancer contrast, in addition to their colorful characteristics, anthocyanins possess potent antioxidant of! Like ginger and antiproliferative activities in some types of cancer has antimicrobial, antinociceptive, antiatherosclerotic, and. Co-P alloy antiglycation activity Zingiberaceae family that is widely distributed throughout the tropics, particularly in Asia. Activity and mechanism in human inflammatory zingiber zerumbet cancer disease aldose reductase compared to the flavonoid family straight. Bitter ginger, shampoo ginger has the ability to inhibit the proliferation of non-malignant Chang liver and MDBK lines!, SK-MEL-2, and after a lifetime of straight hair actually made it curly lots... Review of the eight fractions, fraction V was separated into two subfractions, Va and Vb, Toyoperal... Zerumbet Smith, Hedychium coronarium Koenig and Etlingera cevuga Smith evidenced by several investigations [ 135 ] is. Was suggested as one of the plant are used as a molecule for formulation.... Cells and subjected to Abstract the results demonstrate increased local iNOS activity TNB-Induced! Ether component is a natural product found in many tropical countries, this potent immunomodulator has been further correlated humulene! Zer has been shown to be explored, is a cytotoxic component isolated from Zingiber zerumbet Smith, coronarium...