pounds that modulate the activity of a target that is potentially implicated in a human disease. Biological definition is - of or relating to biology or to life and living processes. 22 examples: The striving to integrate and cohesively direct action is a basic form of… IN A NUTSHELL 5 Activity No. There are innumerous studies comparing the biological actions and in vitro antioxidant activity of phenolic compounds in function of its content in plant‐based foods and consequently, in humans. Enzyme structures may also contain allosteric sites where the binding of a small molecule causes a conformational change that increases or decreases activity. Most people conceptualize the field of psychology as being the study of mental processes and behavior. Glutamate is highly abundant in the brain and throughout nervous tissue, where it is the primary excitatory neurotransmitter. 1. biological assay: [ as´a ] determination of the purity of a substance or the amount of any particular constituent of a mixture. ICH Q6B Definition Potency Learn the definition, its process, types and real-life examples. The carbocyclic analogue of 5-phosphoribosyl-1-pyrophosphate (cPRPP, Figure 17) is the only reported carbafuranose with significant biological activity … Such a center is a distinct anatomical-physiological entity, analogous to brain centers that … 1a).However, there was no significant effect of the substrate nor of the 15 N application rate on cumulative CO 2 –C evolution. Examples for improving biological activity: improving drainage, balancing fertilizer use,reducing compaction, adding manure/compost, reducing soil disturbance or planting a cover crop. n. The effect of a given agent, such as a vaccine, upon a living organism or on living tissue. Define bioactivity. stimulation of cell proliferation) on a defined cell type, under standardized conditions. The biggest factor in biological activity in the soil is the amount of organic matter present. Definition. In humans, we see the circadian rhythm , or the rest-activity cycle, controlled primarily by light. Chemical synthesis and biological activity of peptides incorporating an ether bridge as a surrogate for a disulfide bond ... Disulfide bridges contribute to the definition and rigidity of polypeptides, but they are inherently unstable in reducing environments and in the presence of isomerases and nucleophiles. Biological definition, pertaining to the science and application of biology: the biological substrata; conducting biological tests. Biological weathering only refers to weathering caused by organisms -- animals, plants, fungi and microorganisms such as bacteria. Based on the definition of the most essential terms and concepts of biological diversity and the learning exercises that you have done, please feel free to write your arguments or lessons below. Bioavailability definition is - the degree and rate at which a substance (such as a drug) is absorbed into a living system or is made available at the site of physiological activity. Thus the biological activity of a cytokine is measured by its effect (e.g. A definition of biological activity is proposed that is superficially analogous to the equation relating the thermodynamic activity of a solute to its concentration via an activity coefficient. Biodiversity is the establishment of Ecosystem administrations to which human prosperity is personally connected. Biological Farming combines the best of conventional and organic farming with an emphasis on attaining naturally productive soils that display high levels of biological activity. Definition of BIOLOGICAL ACTIVITY in the Definitions.net dictionary. chemotaxis or cell proliferation assay, enzyme assay, or a functional ELISA. Session Poster Discussion session - CNS tumours. biological action. When a drug is a complex, biological activity is exerted by the substance's active ingredient or pharmacophore. Citation. Central to all biological activity within inland aquatic ecosystems is biological productivity or aquatic production. Most critically, enzymes catalyze all aspects of cell metabolism. We show that one can infer the bioactivity of compounds by assessing the activity of transcription factors (TFs) that regulate gene expression. • The assay demonstrating the biological activity should be based on the intended biological effect which should ideally be related to the clinical response. The Biological Activity Spectrum of a chemical compound is the set of different types of biological activity that reflect the results of the compound's interaction with various biological entities. Presenters Martin Bexon. How to use biological in a sentence. Biological farming is about looking at the whole agronomic, environmental picture, nutritional and biological components of what constitutes a healthy soil. It is known that the biological components occupy less than 0.5% of the total soil volume and make up less than 10% of the total OM in soil. Biological Activity of Carbafuranoses. Biological Approach: Definition. To this end, compounds are typically tested in a range of in vitro biological assays designed to measure primary activities (potency, intrinsic activity, and/or efficacy), selectivity (activity … WHO provides Biological Reference Materials which serve as reference sources of defined biological activity expressed in an internationally agreed unit. The cumulative CO 2 –C evolution ranged between 23 and 32 mg g −1 OM (Fig. Information and translations of BIOLOGICAL ACTIVITY in the most comprehensive dictionary definitions resource on the web. Microbial activity, measured as CO 2 –C evolution, was constant over the period of incubation. The amount of biological activity that breaks down minerals depends on how much life is in that area. Examples of biological activity in a sentence, how to use it. Learn more about enzymes in this article. READ: What is a Sand Dune: Formation and Types of Sand Dunes As much as these compounds are produced through biological process, they arise out of bio-chemical reactions which accelerate chemical and physical weathering. Biological activity also called pharmacological activity describes the beneficial or adverse effects of a drug on living matter. IAS 41 sets out the accounting for agricultural activity – the transformation of biological assets (living plants and animals) into agricultural produce (harvested product of the entity's biological assets). biological assay bioassay; determination of the potency of a drug or other substance by comparing the effects it has on animals with those of a reference standard. Biological rhythms are cyclical activities that are a basic characteristic of animal life. • potency is the quantitative measure of biological activity based on the attribute of the product, which is linked to the relevant biological properties. Biological activity in soils has been shown to promote the dissolution of silicate minerals (see discussion in, but there is still uncertainty surrounding how quickly this may happen. What does BIOLOGICAL ACTIVITY mean? Due to a protein’s ability to exert multiple biological activities, several acceptable bioassays may exist for a particular protein and several different cell types may respond. In the environment, there are in fact 3 types of weathering that occur namely Physical Weathering, Chemical Weathering, and Biological Weathering. Biological Weathering is a natural phenomenon that occurs on rocks due to living organisms. Enzyme, a catalyst that regulates the rate at which chemical reactions proceed in living organisms without itself being altered in the process. While certain forms of biological weathering, such as the breaking of rock by tree roots, are sometimes categorized as either physical or chemical, biological weathering can be either physical or chemical. Using a multiplex reporter system, the FACTORIAL, we characterized cell response to a compound by a quantitative signature, the TF activity profile (TFAP). 5581 - Understanding Biological Activity, Tumor Response and Pseudoprogression in a Phase-2b Study of MDNA55 in Adults with Recurrent or Progressive Glioblastoma (GB) Date 20 Oct 2018. 4.1. 5. As well as being a building block of proteins, glutamic acid (specifically, glutamate) also acts as a neurotransmitter in the central nervous system. Assessing the biological activity of compounds is an essential objective of biomedical research. Biological Activity of Glutamic Acid Glutamate as a Neurotransmitter. The biological activity of a recombinant protein is routinely measured using a bioassay, e.g. bioactivity synonyms, bioactivity pronunciation, bioactivity translation, English dictionary definition of bioactivity. 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